Abstract:The“people-centered” development thought transcends the practical paradox of Western humanism discourse and the simple "people-based" thought of ancient China, inherits and continues Marx's people-centered thought. It is the theoretical manifestation of historical materialism and the practical expression of the CPC's original aspiration of pursuing happiness for the people. The people-centered thought and the basic policy of taking economic development as the central task is connected by the basic line of development, and our original aspiration and ultimate goal of development is to serve the people. We should remain true to this aspiration and keep the mission firmly in mind of pursing development and happiness for the people. The people-centered principle is based on people-oriented logic, refutes the hidden development boundary of the Western“material-oriented” logic, human alienation, and inherent defects of capital, and safeguards people's economic rights, political rights, cultural rights, social rights, and ecological rights, helping achieve harmony between man and nature, man and society, and among human relations. Therefore, the people-centered principle represents the fundamental stance of putting people first, the idea of taking people as the primary driving force for social progress, the fundamental goal of people sharing the benefits of development, and the conception of taking people's judgment as evaluation criterion. It is followed through in the process of battling against poverty, responding to people's yearning for better life, and realizing comprehensive human development, and it is of theoretical value and practical significance for the realization of the great rejuvenation of the Chinese nation.