Abstract:“People’s livelihood” is a comprehensive concept covering economy, politics, society, culture, and even ecological environment. It is also an important content in economic research. From the perspective of economics, “people’s livelihood” mainly refers to the economic activities and laws related to people’s livelihood. It is a dialectical unity between economic base and superstructure. The rational hypothesis of economics on people’s livelihood should be based on value rationality rather than self-interest rationality. In terms of paradigm structure, as both an old and new scholarship, economics on people’s livelihood should absorb the essence of the classics on people’s livelihood at all times and in all countries. Using it as a base, we need to use the principles, methods and views of market economy to analyze the reality of people’s livelihood in the regions and countries studied so as to construct and improve a scientific paradigm structure. The important task of the paradigm of the economics on people’s livelihood is to analyze the laws related to people’s livelihood in economy, probe into specific causes of problems, and translate the paradigm into practice, serve the general public and achieve mutual development.